Effectiveness of mineral water application on the functional state of the liver in individuals after cholecystectomy at the long-term rehabilitation stage as a prerequisite for creating individualized rehabilitation programs

Authors

DOI:

https://doi.org/10.32540/2071-1476-2024-3-217

Keywords:

cholecystectomy, liver function, hydrotherapy, hydrotherapyphysical rehabilitation, physical therapy, metabolic syndrome, health, health management, rehabilitation program

Abstract

Introduction. Liver function in people after cholecystectomy is of great importance because it has vital functions. The purpose of the study is to determine the effectiveness of the use of mineral water on the functional state of the liver of people after cholecystectomy at the long-term stage of rehabilitation as a prerequisite for the creation of individual rehabilitation programs in the conditions of the Morshinkurort sanatorium-resort complex. Research methods: an analysis of 100 medical records of people after laparoscopic cholecystectomy was carried out. People used mineral diluted therapeutic water (DMW) of the well No. 3-k in the village of Horishne, Stryi district, Lviv region at a dilution of 3.0-3.4 g/dm3 when used internally. MRW is a product of dilution in certain proportions of underground brines from well No. 3-K and groundwater from source No. 4 in the city of Morshyn to a mineralisation of 3.0-3.4 g/dm3. Medical cards were selected by a randomized method using the Random Allocation Rule program. Blinding of evaluators in the processing of medical cards. Methods of mathematical statistics – Student’s t-test. The investigated indicators: total protein (g/l), thymol test (units), total protein, alanine transpeptidase (ALT, mmol (h.l.)), aspartate transaminase (AST, mmol (h.l.)), total cholesterol (mmol/l), triglycerides (un.l), blood sugar. The results. Impaired liver function in people after cholecystectomy in the long-term rehabilitation stage is a risk of developing metabolic syndrome. The use of mineral diluted therapeutic water from well No. 3 of the village of Horishne in a concentration of 3.0-3.4 g/dm3 for at least 14 days at the long-term stage of rehabilitation in persons after laparoscopic cholecystectomy led to a statistically significant difference (improvement) in the protein-synthesising function of the liver – the Thymol test decreased from 4.23±0.45 to 2.21±0.42 units (p<0.01). The activity of alanine transpeptidase ALT decreased, from 0.98±0.11 to 0.68±0.10 mmol/(h·l), (p<0.05), which indicates the recovery of liver cells. There was a decrease (p<0.05) in the total cholesterol level from 6.21±0.37 to 5.23±0.32 mmol/l. Conclusions. Hydrotherapy at the long-term stage of rehabilitation leads to improved liver function in people after laparoscopic cholecystectomy.

References

Golod NR, Churpiy IK, Slobodian NG, Mukan NM, Yaniv OV. Analiz metodyky reabilitatsii patsiientiv pislia kholetsystektomii na viddalenomu etapi reabilitatsii [Analysis of rehabilitation techniques for patients after cholecystectomy at a remote stage of rehabilitation]. Art of Medicine (Scientific and practical journal). 2019);4(12):34-7

Golod NR, Yaniv OV, Fedorivska LP. Efektyvnist zastosuvannia mineralnoi vody ta diiety na funktsionalnyi stan pechinky u patsiientiv pislia laparoskopichnoi kholetsystektomii v dovhotryvalomu periodi reabilitatsii [Effectiveness of application mineral water and diet on the functional state of the liver in patients after laparoscopic cholecystectomy in the long-term rehabilitation period.]. In: Materialy vseukrainskoi naukovo-praktychnoi konferentsii z mizhnarodnoiu uchastiu “perspektyvy rozvytku medychnoi ta fizychnoi reabilitatsii na riznykh rivniakh nadannia medychnoi dopomohy”. 2020 September 29–30; 2022, p. 28-30

Altomare DF, Rotelli MT, Palasciano N. Diet After Cholecystectomy. Current medicinal chemistr. 2019;26(19):3662-5. https://doi.org/10.2174/0929867324666170518100053

Amaral Raposo M, Sousa Oliveira E, Dos Santos A, Guadagnini D, El Mourabit H, Housset C, Lemoinne S, Abdalla Saad MJ. Impact of cholecystectomy on the gut-liver axis and metabolic disorders. Clinics and research in hepatology and gastroenterology, 2024;48(7):102370. Advance on-line publication. https://doi.org/10.1016/j.clinre.2024.102370

Arora D, Kaushik R, Kaur R, et al. Post-cholecystectomy syndrome: A new look at an old problem. Journal of Minimal Access Surgery. 2018;14:202-7. https://doi.org/10.4103/jmas.JMAS_92_17

Çalişkan N, Bulut H, Konan A.. The Effect of Warm Water Intake on Bowel Movements in the Early Postoperative Stage of Patients Having Undergone Laparoscopic Cholecystectomy: A Randomized Controlled Trial. Gastroenterology nursing: the oficial journal of the Society of Gastroenterology Nurses and Associates. 2016;39(5):340-7. https://doi.org/10.1097/SGA.0000000000000181

Cheng ML, Nakib D, Perciani CT, Mac Parland SA. The immune niche of the liver Clinical science (London, England: 1979. 2021;135(20):2445-66

Daniels LJ, Kay D, Marjot T, Hodson L, Ray DW. Circadian regulation of liver metabolism: experimental approaches in human, rodent, and cellular models. American journal of physiology. Cell physiology, 2023);325(5):1158-77. https://doi.org/10.1152/ajpcell.00551.2022

Di Ciaula A, Garruti G, Wang DQ, Portincasa, P. Cholecystectomyand risk of metabolic syndrome. European journal of internal medicine. 2018;53:3-11. https://doi.org/10.1016/j.ejim.2018.04.019

Fromenty B, Roden M. Mitochondrial alterations in fatty liver diseases. Journal of hepatology. 2023;78(2):415-29. https://doi.org/10.1016/j.jhep.2022.09.020

Golod N, Buhaienko T, Imber V, Kara S, Zastavn O, Prysiazhniuk O, Kravchuk M. The Results of the Examination of Patients After Laparoscopic Cholecystectomy in the Acute Period of Rehabilitation Using the International Classification of Functioning. Acta Balneologica. 2022;3(278):222-9

Golod N, Saienko V, Liannoi M, Rusyn L, Yaniv O, Ivanovska O. The dynamics of recovery of external breathing function in patients after laparoscopic cholecystectomy in the acute period under the influence of the rehabilitation program. Wiadomości Lekarskie. 2024;77(2):208-13. https://doi.org/10.36740/WLek202402104

Golod NR, Churpiy IK, Yaniv OV, Buhaienko TV, Bespalova OO, Rohalya YL, Sabadosh MV. The Influence of the Application of Mineral Water on the Functional State of the Liver of Patients after Laparoscopic Cholecystektomia in the Long Period of Rehabilitation. Acta Balneologic. 2022;1(167):29-33

Golod NR, Rusyn LP, Churpiy IK, Zakaliak NR, Saienko VG, Meleha KP, Dutkevych-Ivanska YV. Dynamics of the Level of Functioning of Patients After Laparoscopic Cholecystectomy in the Long-term Rehabilitation Period. Acta Balneologica. 2022;6(172):537-41

Hassler KR, Collins JT, Philip K, Jones MW. Laparoscopic Cholecystectomy. In StatPearls. StatPearls Publishing. 2023

Jensen SW, Gelbel J. Postcholecystectomy Syndrome Clinical Presentation. Medscape. [Updated 28 Nov 2018]

Lala V, Zubair M, Minter DA. Liver Function Tests. In StatPearls. StatPearls Publish ing. 2023. https://www.ncbi.nlm.nih.gov/books/NBK482489/

Lange AH, Pedersen MG, Ellegaard AM, Nerild HH, Brønden A, Sonne DP, Knop FK. The bile-gut axis and metabolic consequences of cholecystectomy. European journal of endocrinology. 2024;190(4):R1–R9

Mennuni G, Petraccia L, Fontana M, Nocchi S, Stortini E, Romoli M, Esposito E, Priori F, Grassi M, Geraci A, Serio A, Fraioli A. The therapeutic activity of sulphate-bicarbonate-calcium-magnesiac mineral water in the functional disorders of the biliary tract. La Clinica terapeutica. 2014;165(5):346-52

Piantanida E, Ippolito S, Gallo D, Masiello E, Premoli P, Cusini C, Rosetti S, Sabatino J, Segato S, Trimarchi F, Bartalena L, Tanda ML. The interplay between thyroid and liver: implications for clinical practice. Journal of endocrinological investigation. 2020;43(7):885–99. https://doi.org/10.1007/s40618-020-01208-6

Portincasa P, Di Ciaula, A, Bonfrate L, Stella A, Garruti G, Lamont JT. Metabolic dysfunction-associated gallstone disease: expecting more from critical care manifestations. Internal and emergency medicine. 2023;18(7):1897–918. https://doi.org/10.1007/s11739-023-03355-z

Ribas Blasco Y, Pérez Muñante M, Gómez-Fernández L, Jovell-Fernández E, Oms Bernad LM. Low-fat diet after cholecystectomy: Should it be systematically recommended? Cirugia Espanola. 2020);98(1):36–42. https://doi.org/10.1016/j.ciresp.2019.05.009

Published

2024-12-27

How to Cite

1.
Holod N. Effectiveness of mineral water application on the functional state of the liver in individuals after cholecystectomy at the long-term rehabilitation stage as a prerequisite for creating individualized rehabilitation programs. Sportyvnyi Visnyk Prydniprovia [Internet]. 2024Dec.27 [cited 2025Oct.4];(3):217-2. Available from: https://svp.ust.edu.ua/article/view/340364

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